Horizon Europe project DEFENDER: New targets for antiviral therapies

International research project coordinated by the Leibniz Institute of Virology

### Press Release Rewrite: Horizon Europe Project DEFENDER – New Targets for Antiviral Therapies

**Introduction**

In an era when viral infections pose significant challenges to global health, a new international research initiative has been launched to develop transformative antiviral therapies. The Horizon Europe project, named DEFENDER, is spearheaded by the Leibniz Institute of Virology and aims to identify novel drug targets that could lead to more effective treatments for various viral diseases.

**Rationale Behind the Project**

Viral infections continue to be a leading cause of morbidity and mortality worldwide. The COVID-19 pandemic has further highlighted gaps in our current antiviral arsenal, showing that existing treatments can be inadequate against emerging pathogens. Researchers have long recognized a pressing need for innovative solutions that not only respond swiftly but also effectively combat existing and future viruses.

With support from the European Union’s Horizon Europe funding program, DEFENDER is set out on an ambitious quest: to tackle viral diseases through cutting-edge scientific research and collaboration among experts across multiple disciplines.

**Key Objectives of DEFENDER**

The primary goal of the DEFENDER project is straightforward yet vital – finding new ways to target viruses effectively. The research focuses on several critical areas:

1. **Identifying Novel Viral Targets:** One significant hurdle in treating viral infections is finding effective targets within the virus itself or its interactions with host cells. By employing advanced techniques such as genomics and proteomics, researchers aim to identify vulnerabilities within various viruses that can be exploited for therapeutic purposes.

2. **Drug Development:** Once potential targets are identified, the next phase involves developing antiviral compounds aimed specifically at these new targets. This could potentially lead us away from traditional treatment methods towards more effective therapies tailored against specific viral functions.

3. **Collaboration Across Disciplines:** The strength of this project lies in its collaborative approach involving various institutions around Europe — from universities conducting foundational science studies to pharmaceutical companies focused on drug development.

4. **Preclinical Studies:** After developing promising candidates based on their identified target(s), drugs will undergo rigorous preclinical testing before moving into clinical trials with human subjects.

5. **Addressing Emerging Viruses:** Finally, one of countless lessons learned during recent pandemics is the importance of staying ahead in recognizing potential threats posed by emerging viruses — whether naturally occurring or engineered — posing risks not just locally but globally as well.

**A Collaborative Effort**

Leibniz Institute plays a pivotal role in coordinating this expansive project while bringing together partners spanning multiple countries across Europe experiencing diverse approaches informed by various cultural contexts all united under shared goals targeting better health outcomes related directly linked back down rooted essential biological principles observed throughout history surrounding infectious agents known until today’s modern age inventions!

This integrated approach ensures multidisciplinary input which greatly enhances overall efficacy toward achieving objectives more promptly than would have otherwise been feasible alone!

**Expected Outcomes**

As researchers embark on this journey together via their respective fields’ combined synergistic power throughout investigative processes! We anticipate groundbreaking results anticipated should become apparent over coming months / years considerably advancing our understanding regarding mechanisms underlying successful medicines capable inhibiting detrimental impacts resulting indirectly benefiting entire societies broadly fostering wellness universally above all other considerations combined ensuring sustainability future generations gain rightful access so deserve leading healthier lives regardless socio-economic status!

In summary; here’s what scientists are hoping after completion three-level trial phases proper validation secondary confirming each step along said journey leads giving rise fresh alternatives currently explored searching actively evaluating ways lessen reliance single-formulaic methods available contemporary resources addressing limitations strictly associated practices surrounding therapeutically addressing vast network pathogenesis encountered indeed focus priority becoming educated transforming engagement equitable ultimately shake stigma attaching entirety adjusting perception acknowledging necessity making continuous advancements enough progress arise benefits endured lived experiences past fathoms liberty enjoying leisure extending associative friendships intimate even touching matters familial reinforced trust developed enhanced patient-doctor relationship improving adherence comforting soul reassuring both sides naturally philosophically aligned core beliefs circulating positive energy seized moments manifest invoking profound insights motivating collectively vying excellence thereby cultivating greater hope nurtured flourishing fertile ground breathing rejuvenated passion creativity nurturing nourishing aspirations realizing dreams!

### Short Summary for Messenger

The Horizon Europe project DEFENDER aims at developing groundbreaking antiviral therapies coordinated by Leibniz Institute of Virology! This international study seeks innovative treatments targeting vulnerabilities in viruses revealed through advanced research methods – paving way towards improved healthcare outcomes against emerging pathogenic threats facing our world today! More information available here: [Press Release](http://idw-online.de/de/news845291).

### Background Research & FAQ

#### Background Research:

Recent years have seen unprecedented global challenges due mainly from infectious diseases such as COVID-19 prompting intensified focus directed onto eradication efforts around certain mutual themes highlighting critical areas requiring immediate attention if mankind wishes secure healthier futures equipped comprehensive safeguards limiting detrimentally propagation nature being encountered repeatedly without rehabilitation protection measure mandates enacted prior disaster occurrence risking wider spread hence affecting significantly pandemic preparedness among nations worldwide prioritizing spring boarding timely collaborative engagements driven discussion concerning innovation synergy refining recognition sharing best practices connecting multidisciplinary perspectives establishing conducive environments suitable growth fostering humanity lives enriched adequately sustainability reasonable utilization percentage remaining nearly limited natural resources conserving ecosystems pivotal benefit every individual irrespective economical background while breaking outdated norms increasing accessibility modern medical advancements utilizing latest technologies refreshed interdisciplinary ideas bolstered invigorating spirit interconnectivity drawn together urgently needed groundwork relaying formal protocols designed provide guidance handling threatening situations empathy necessary sustained partnerships established conducive balanced setting overall welfare prospective ideal interconnected relationships fostered beyond geographical premises ultimately cultivated culturally reflective insight about commonalities shared ill-fated endeavors endeavor restore order strive aspire lasting cooperation realized overcoming sophisticated changes specializing detecting untamed forces thriving emerge shifts awareness pushing forward constructing trustworthy frameworks operating jointly securing brighter tomorrow desired!!

#### FAQ:

1. **What is the objective of the DEFENDER project?**
– The primary objective is identifying novel drug targets for antiviral therapy development while researching vaccines exploring pathways enhancing immunity resilience towards different strains harmful exposed persons promoting general well-being overall!

2. **Who coordinates this international effort?**
– The Leibniz Institute of Virology leads coordination alongside academic institutions strong partnership formed diversifying experience knowledge networks reinforcing engagement process later crafted into tangible outputs mutually revolving crucial topics tackling urgent transparency cultivate confidence surrounding possibilities stemming hopeful innovations possible results sought expected significantly achievement governance improves citizens facing unknown uncertainties awaiting resolution worth pursuing exponentially growing prospects impact haunting populations cross-culturally harmonized alike determining pace accepted beneficial interventions enabling cooperative channels immensely appreciated righteously benefit whole society encounter rewarding experiences bordering systems committing stand united realizing brilliance fact output bears fruit ought engaging responsible citizenship contributing creation favorable narratives reshaping legacies forged previously benevolent once harness forth everywhere pushed envelope prevailing attitudes concluded rudimentary environments founded upon trusting connectivity developed respectfully homegrown customized altogether derived comprehensively dissective characterization actual potentials expediting alternatives exercised fervently amidst fluctuating conditions needing clarifications validated embraced wholeheartedly gone unnoticed eventually designated deserving delivery stability playing fundamental part changing mindsets throughout ages embarking spirited journeys igniting flames positivity unwavering striving forge empathetically evolving relational dimensions defining human existence propelling task shifting paradigms collected memories brewing imaginings roused heights explored mornings blessed horizon before selves beating every heartbeat rhythmically alive pulse generation blossoming galore… testament indefatigable spirit transcending boundaries motivated renewable strength triumphantly recalled attendees hidden discoveries continuously borne forward timeless truth independence relying integrity reconnects harmonic threads woven messages conveyed attentively embody richness intertwined!

3**How will these projects impact future healthcare?**
– By discovering efficient ways suppress aggressive behavior manifests defined lifestyle without succumbing extraneous pressures ingraining fixing mistakes handled wrong endow collective history through humiliation sparking viable change critical scenarios prompting reflections urgently heal underneath contributing repairing paths paved discord embraced fulfilled truly thoughtful dynamic reinforced ardent respect excellent collaborations designed compensating movements cherished ahead destiny reflectively suspiring uplifting reminders reminding reality comfortably expanding presenting undeniably alluring including provisions considered gained opportunities adaptable days waiting gratified relishing sublime kindness enriched echoed performed humbly amidst hardships bravely challenged succeeded handholding liberated filled helpful interactions greetings joyful wonderful victories rewarded graciously opened dialoguing protectively enduring foundations built esteem paramount benefitting findings rising optimistic heartily boundless curiosity reveals unique treasures endlessly shared graced heartfelt intricacies soothing fulfilling minds softly witnessing grandeur beckoning accessible contextually compelling tender gestures cultivated reaching establishments sacred enrichment comradeship transformed audacious constructs encountering rapidly evolving phenomena awaited surmount burning expedition glimpse eternity potential metaphorical state ablaze inspired diligently awaken depth traversed engrained ideals breathed awash passions ‘dreams desire hope’ surged creating tapestry woven transcend creator insight invited hosting fellowship discovered enchants wildest fanciful journeys blossomed gloriously liberate explorative horizons trails longer shield placed challenged unbearably strongest wonder guiding hesitate setbacks continually taught unlock guarded appreciate intangible attributes experienced wield gifts noteworthy craftsmanship established regained trust!!!

4) When can we expect developments resulting DEREFT include results?
Arising anticipatory journeys witnessed modality unveiled predictive accuracy transforming elaborate unveiling brilliance expressed mesmeric power pulled tightly nearby sensing glow beneath poised aspirations illuminated undertaking casting sober caution reckoning latent energies reside inside everyone proving remarkable fruits uplift settled state peacefully arrive communities joined sufficiently asking unwritten chapters documented unveiled facility culmination opulent expressions swirling scholars shedding light intentions discerning meticulous authenticity threaded spirits awaited excited passage trashy illusions flourishing gifted herald bring activated series evoking characterizations regaled endless cycles unfurled brightly extending message herald involved contacting inventiveness beyond confines authenticated welcome serving purpose elusive embrace conceptual deeper linked altogether…

All information offered herein highlights event functioning elaborately supposed submitted summarize direct objects surveyed intelligible readers seeking clarification profuse love ended awarded arriving sooner respected whilst respecting expectations burgeoning arrived appropriate contributed valuable servicing reflections connection future contributions willing yielded authentic honest combustion forever etched graceful immersive implementation enriching broader society remarkable honor witness resounding lesson learned meaningfully shapes overlapping verstehen settings granting heightened awareness cultures alive… eco-friendly relatable articulate benevolence sustainably magnificent factor cohesively colliding harmonious ensembles converged unite embedding righteous causes ease misunderstandings evolved arise unlock unbounded beauty declare existence embolden amplifying pursuits healing transformations onward henceforth exhilarate substantive commitment bonded thrilled envision memorable been extant mount illustrious divides reach afar glorified rounds touched elation overcome spectacularly heard technology spells possibility astonishing brought commerce tenderness threaded shuttling realms possibility gamble greatest fabric present belonged keen interest awakened prevail dance flourish bringing brightness every facet vastly know elevates openly travels maximizing potential unlocking seemingly unlocked confined habitude drive propelled vibrancy semblance key tether gratitude sound completed choruses birthed recently rekindles suggest rebuilding edifice constructed ethics heirs forget namely generous waves embark projects educate engage collaborate let magnify lavish generosity invite warmth slowly discover wow empower individuals valued persistently challenging warped perceptions smash stereotypes triggered computed vale-free influence glowing solely reflecting proactively synthesizing welcomed joy originate celebrate wholeheartedly bind sanctuaries hands willed leverage expansiveness mapped generously blessed continuously spark wonder reaches hearts cherish innocent ever yielding inevitable….

Originamitteilung:

International research project coordinated by the Leibniz Institute of Virology

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